{"id":1,"date":"2019-04-26T10:08:19","date_gmt":"2019-04-26T10:08:19","guid":{"rendered":"http:\/\/nerb.team\/?p=1"},"modified":"2020-10-04T20:43:09","modified_gmt":"2020-10-04T20:43:09","slug":"hello-world","status":"publish","type":"post","link":"https:\/\/nerb.team\/index.php\/2019\/04\/26\/hello-world\/","title":{"rendered":"Research"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Our research focus is on the\u00a0<strong>Acquisition and Regulation of Repetitive Behaviors.<\/strong>\u00a0More specifically,our team study the behavioral and neurophysiological\u00a0<strong>dynamics underlying the automatization<\/strong>\u00a0of motivated behaviors and\u00a0<strong>its contextual adaptation<\/strong>. We are especially interested in studying how cortico-basal ganglia loops underlie these processes. We aim to probe these neural circuits by using electrophysiological recording and\/or modulating their activity with electrical, optical or chemical (DREADD) stimulations. Importantly, we have the skills, technical knowledge, and\u00a0<strong>access to both patients and animal models suffering from pathological repetitive behaviors to implement our research program<\/strong>. Indeed, repetitive behaviors are the hallmark of some related neuropsychiatric disorders, which offer a unique opportunity to explore the neurobiological mechanism underlying their regulation. In these pathologies, the inability to regulate the expression of learned behaviors often has deleterious behavioral consequences. We propose to use these pathological conditions in human and rodents as models to better understand the neurophysiology of adaptive behavior. Thus, our studies include the use of animal models (e.g. SAPAP3-KO mice to model repetitive behaviors, PV-Cre mice with optogenetic to model a decrease of striatal interneurons activity, etc.) and patients suffering from both compulsions and tics (OCD\/Tourette\u2019s syndrome, cocaine addiction).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our research focus is on the\u00a0Acquisition and Regulation of Repetitive Behaviors.\u00a0More specifically,our team study the behavioral and neurophysiological\u00a0dynamics underlying the automatization\u00a0of motivated [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - 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