Principal Investigator
Computational Neuroscience and Psychiatry


e-mail: philippe.domenech(at)


I’m interested in how the brain supports flexible and adaptive behavior in changing and uncertain environments. To tackle this issue, I use tools from computational neurosciences and neurophysiological/imaging recordings (MRI, EEG/MEG, intracranial EEG) of human brain activity while it’s engaged in dynamically controlling decision-making processes. As a psychiatrist specializing in treatment-resistant OCD/depression and neuromodulation, I’m also interested in using the same approach to study the computational underpinning of psychiatric diseases.

Selected bibliography :

  • Domenech, S. Rheims, E. Koechlin, « Neural mechanisms resolving exploitation-exploration dilemmas in the medial prefrontal cortex », Science, 2020.
  • Lopez-Persem, J. Bastin, M. Petton, R. Abitbol, K. Lehongre, C. Adam, V. Navarro, S. Rheims, P. Kahane, P. Domenech, M. Pessiglione, “Testing the core properties of the brain valuation system: an intracranial electrophysiology investigation in humans”, Nature Neuroscience, 2020.
  • Senova, L. Mallet, J.M. Gurruchaga, C. Rabu, M. Derosin, J. Yelnik, P. Brugières, A. Pelissolo, S. Palfi, P. Domenech, “Complete remission of a severe NBIA-associated OCD after STN-DBS”, Biological Psychiatry, 2019.
  • Domenech, J. Redouté, E. Koechlin and JC. Dreher, «A neuro-computational account of economic choices », Cerebral Cortex, 2017.
  1. Domenech and E. Koechlin, « Executive control and decision-making in the prefrontal cortex », Current Opinion in Behavioral Science, 2015