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Luc Mallet

MD, PHD, PU-PH, APHP

Date and place of birth : 20th January 1967, Paris (XIV)

ORCID : 0000-0001-8061-1167

E-mail : luc.mallet@inserm.fr ; luc.mallet@unige.ch

MD PhD, he was trained in Psychiatry and Neurosciences. He has been Professor Assistant in the University Department of Psychiatry in Paris 12 (Créteil) and Paris 6 (Pitié-Salpêtrière) and worked on functional imaging at the CEA. After his post-doctoral training in experimental psychology in a CNRS research unit, he was recruited at the Inserm in 2004 to study the behavioral aspects of the deep brain stimulation in human, and to develop innovative treatments in psychiatry. Since 2008, he leads the BEBG team in the Brain and Spine Institute (ICM), wherein the main focus of research is the identification of processes involved in the treatment of information by the basal ganglia and its links to psychopathology, as well as the development of innovative treatments for severe neuropsychiatric disorders that are resistant to medical therapy. In particular, he coordinates a series of translational research projects aimed at characterizing the pathophysiology of repeated pathological behaviors in humans, including obsessive-compulsive disorder (OCD). Since 2020, he started to develop a translational program research with Eric Burguière on psychedelics for the treatment of psychiatric disorders, with the use of LSD for the treatment of severe alcohol dependence and psilocybin for OCD.

 

Position: Professor of Psychiatry, Département Médical-Universitaire de Psychiatrie et d’Addictologie, APHP, UPEC, Créteil, France; Associate Professor, Psychiatric Department & Institute of Global Health, University of Geneva; ICM (Paris Brain Institute) researcher; Chief Editor of CQFPSY (Congrès Français de Psychiatrie Newsletter)

Education: Residency in Psychiatry, Paris 5 University, 1996; M.D., Paris 5 University, 1996 ; Neuroscience Post-graduate Diploma (DEA), Orsay CEA-DSV, Paris 6 University, 1993; PhD Thesis on functional imaging (2002, UPMC, CEA, France); Post-doctoral training in experimental psychology (2002-2004, CNRS, France)

Awards, honors: French Academy of Sciences Philippe and Maria Halphen Great Prize in 2015; Marcel Dassault prize for the research in mental diseases, “researcher of the year” 2013 ; STOC project (Stimulation of the subthalamic nuclei for the treatment of severe and resistant OCD, coordinated by L Mallet) distinguished in 2013: 20 years of the PHRC – 20 projects selected, Health Ministry, France

Boards, learned societies, memberships, expertise: General Secretary fo the Congrès Français de Psychiatrie, Secretary of the French Brain Council, Steering Committee of the LABEX BIOPSY (Paris), Scientific Advisory Board Member of the ERA-Net NEURON (Network of European Funding for Neuroscience Research) 2015-2020, Director of the FondaMental Swiss Foundation (Geneva 2015-2021)

Ongoing Grants: IRESP21 ADELY : Treatment of Alcohol DEpendence with LYsergic acid diethylamide: translational approach and clinical efficacy study (PI); ANR SAMENTA HYPSY : HYperdirect pathway in PSYchiatry: Anatomo-functional characterization of the cortical-subthalamic pathway and its relevance for the treatment of OCD by deep-brain stimulation (Co-PI; no overlap); STUC – PHRC AOR11036: SCP pilot study of cocaine users with addiction and severe complications ( PI, no overlap); Fondation Privée des HUG – CONFIRM : OptoDBS: deep brain stimulation treatments for obsessive-compulsive disorders based on optogenetic circuit explorations. (Co-PI, no overlap); Fondation pour la Recherche Medicale – TORPIDO: Towards identification of response predictors in deep­brain stimulation of subthalamic nucleus for obsessive compulsive disorder. (PI, no overlap)

Student supervision: 8 PhDs, 2 MDs; one ongoing PhD.

Publications:

Lamothe, H., Tamouza, R., Hartmann, A., & Mallet, L. (2021). Immunity and Gilles de la Tourette syndrome: A systematic review and meta‐analysis of evidence for immune implications in Tourette syndrome. European Journal of Neurology.

Arumugham, S. S., Srinivas, D., Narayanaswamy, J. C., Jaisoorya, T. S., Kashyap, H., Domenech, P., Palfi, S., Mallet, L., Venkatasubramanian, G., & Reddy, Y. J. (2021). Identification of biomarkers that predict response to subthalamic nucleus deep brain stimulation in resistant obsessive–compulsive disorder: protocol for an open-label follow-up study. BMJ open, 11(6), e047492.

Benzina, N., N’diaye, K., Pelissolo, A., Mallet, L., & Burguière, E. (2021). A cross-species assessment of behavioral flexibility in compulsive disorders. Communications Biology, 4(1), 1-12.

Lamothe, H., Schreiweis, C., Lavielle, O., Mallet, L., & Burguière, E. (2021). Not only compulsivity: The SAPAP3-KO mouse reconsidered as a comorbid model expressing a spectrum of pathological repetitive behaviors. bioRxiv, 2020-01.

Yrondi, A., Vaiva, G., Walter, M., Amato, T. D., Bellivier, F., Bennabi, D., … & Horn, M. (2021). Childhood Trauma increases suicidal behaviour in a treatment-resistant depression population: a FACE-DR report. Journal of psychiatric research, 135, 20-27. IF: 3.7

Baptista, A., Maheu, M., Mallet, L., & N’Diaye, K. (2020). Joint contribution of metacognition and self-beliefs to uncertainty-guided checking behavior. Psyarxiv, 2020

Welter ML, Flores Alves Dos Santos J, Clair AH, Lau B, Mamadou Diallo H, Fernandez-Vidal S, Belaid H, Pelissolo A, Domenech P, Karachi C, Mallet L. Deep brain stimulation of the subthalamic, accumbens or caudate nuclei for patients with severe obsessive compulsive disorder: a randomized cross-over controlled study, Biological Psychiatry, https://doi.org/10.1016/j.biopsych.2020.07.013

Buot A., Karachi C., Lau B., Belaid H., Fernandez-Vidal S., Welter M.-L. & Mallet L., Emotions modulate subthalamic nucleus activity: new evidence in obsessive-compulsive disorder and Parkinson disease patients, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging (2020), doi: https://doi.org/10.1016/j.bpsc.2020.08.002.

Alves B, Mauvieux B, Besnard S, Lemarchand B, Mallet L, Jouffroy R, Étude de la cinétique per-effort des paramètres des gaz du sang veineux au cours d’un ultra-trail, Science &Sports (2020) 35, 58-60.

Lamothe, H., Schreiweis, C., Mallet, L., & Burguiere, E. (2020). The Sapap3-knockout mouse model manifests a spectrum of repetitive behaviours. bioRxiv.

Oliveira, J., Maia, A., Lajnef, M., Mallet, L., Tamouza, R., Leboyer, M., & Oliveira‐Maia, A. J. (2020). Opportunities and challenges in meta‐analyses of oxidative and nitrosative stress markers in neuropsychiatric disorders. Acta Psychiatrica Scandinavica, 141(1), 89-90.

Senova, S., Clair, A. H., Palfi, S., Yelnik, J., Domenech, P., & Mallet, L. (2019). Deep Brain Stimulation for Refractory Obsessive-Compulsive Disorder: Towards an Individualized Approach. Frontiers in Psychiatry, 10.

Senova, S., Rabu, C., Beaumont, S., Michel, V., Palfi, S., Mallet, L., & Domenech, P. (2019). Stimulation du nerf vague dans le traitement de la dépression. La Presse Médicale, 48(12), 1507-1519.

Benzina, N., N’Diaye, K., Pelissolo, A., Mallet, L., & Burguière, E. (2019). A cross-species assessment of behavioral flexibility in compulsive disorders. bioRxiv, 542100.

Benzina, N, Morgiève M, Euvrard M, Flores Alves Dos Santos J, Pelissolo A, Mallet L.  (2019). Personalised 360 video exposure therapy for the treatment of obsessive-compulsive disorder: a proof-of-concept study. psyRxiv

Senova, S., Mallet, L., Gurruchaga, J. M., Rabu, C., Derosin, M., Yelnik, J., … & Domenech, P. Severe Obsessive-Compulsive Disorder Secondary to Neurodegeneration With Brain Iron Accumulation: Complete Remission After Subthalamic Nuclei Deep Brain Stimulation. Biological Psychiatry. 2019

Jouffroy, R., Alves, B., Mauvieux, B., Mallet, L., Beaudeux, J. L., & Cottart, C. H. (2019, September). NSE & S100B protein blood level assessment during a long-distance trail race. In Annales de biologie clinique (Vol. 77, No. 5, pp. 532-536).

Morgiève, M., N’diaye, K., Nguyen-Khac, A., Mallet, L., & Briffault, X. (2019). Crazy’App: A web survey on representations and attitudes toward mental disorders using video testimonies. L’Encéphale, 45(4), 290-296.

Lamothe H, Baleyte J-M, Mallet L, Pelissolo A ‘Trichotillomania is more related to Tourette disorder than to obsessive compulsive disorder’, Brazilian Journal of Psychiatry, 2019

Mallet, L., Du Montcel, S. T., Clair, A.-H., Arbus, C., Bardinet, E., Baup, N., Chabardès, S., Chéreau, I., Czernecki, V., Fontaine, D., Harika-Germaneau, G., Haynes, W. I., Houeto, J.-L., Jaafari, N., Krack, P., Millet, B., Navarro, S., Polosan, M., Pelissolo, A. and Welter, M.-L. (2019) ‘Long-term effects of subthalamic stimulation in Obsessive-Compulsive Disorder: Follow-up of a randomized controlled trial’, Brain Stimulation, 12(4), 1080-1082. doi: 10.1016/j.brs.2019.04.004.

Maia, A., Oliveira, J., Lajnef, M., Mallet, L., Tamouza, R., Leboyer, M. and Oliveira‐Maia, A. J. (2019) ‘Oxidative and Nitrosative Stress Markers in Obsessive‐Compulsive Disorder: A Systematic Review and Meta‐Analysis’, Acta Psychiatrica Scandinavica, pp. 1–14. doi: 10.1111/acps.13026.

Welter, M.-L., Houeto, J.-L., Worbe, Y., Diallo, M. H., Hartmann, A., Tezenas du Montcel, S., Ansquer, S., Thobois, S., Fontaine, D., Rouaud, T., Cuny, E., Karachi, C. and Mallet, L. (2019) ‘Long-term effects of anterior pallidal deep brain stimulation for tourette’s syndrome’, Movement Disorders, (January), pp. 2018–2019. doi: 10.1002/mds.27645.

Lamothe H, Baleyte J-M, Smith P, Pelissolo A, Mallet L. Individualized Immunological Data for Precise Classification of OCD Patients. Brain Sci. 2018;8(8):149.

Trenado C, Boschheidgen M, Rübenach J, N’Diaye K, Schnitzler A, Mallet L and Wojtecki L (2018) Assessment of Metacognition and Reversal Learning in Parkinson’s Disease: Preliminary Results. Front. Hum. Neurosci. 12:343. doi: 10.3389/fnhum.2018.0034

Clair AH, Haynes W and Mallet L. Recent advances in deep brain stimulation in psychiatric disorders [version 1; referees: 2 approved]. F1000Research 2018, 7(F1000 Faculty Rev):699 (doi: 10.12688/f1000research.14187.1)

Haynes WI, Clair AH, Fernadez-Vidal S, Gholipour, B, Morgiève M, Mallet L, Altered anatomical connections of associative and limbic cortico-basal-ganglia circuits in obsessive-compulsive disorder, European Psychiatry, 2018;51:1–8.

  1. Martinez-Ramirez, J. Jimenez-Shahed, J. F. Leckman, M. Porta, D. Servello, F.-G. Meng, J. Kuhn, D. Huys, J. C. Baldermann, T. Foltynie, M. I. Hariz, E. M. Joyce, L. Zrinzo, Z. Kefalopoulou, P. Silburn, T. Coyne, A. Y. Mogilner, M. H. Pourfar, S. M. Khandhar, M. Auyeung, J. L. Ostrem, V. Visser-Vandewalle, M.-L. Welter, L. Mallet, C. Karachi, J. L. Houeto, B. T. Klassen, L. Ackermans, T. Kaido, Y. Temel, R. E. Gross, H. C. Walker, A. M. Lozano, B. L. Walter, Z. Mari, W. S. Anderson, B. K. Changizi, E. Moro, S. E. Zauber, L. E. Schrock, J.-G. Zhang, W. Hu, K. Rizer, E. H. Monari, K. D. Foote, I. A. Malaty, W. Deeb, A. Gunduz, and M. S. Okun, “Efficacy and Safety of Deep Brain Stimulation in Tourette Syndrome: The International Tourette Syndrome Deep Brain Stimulation Public Database and Registry,” JAMA Neurol., vol. 32607, pp. 1–7, 2018.

Welter ML, Houeto JL,  Thobois S, Bataille B, Guenot M, Worbe Y, Hartmann A, Czernecki V,  Bardinet E, Yelnik J, Tezenas du Montcel S,  Agid Y, Vidailhet M, Cornu P, Tanguy, A, Ansquer S, Jaafari, N, Poulet, E, Serra G, Burbaud, P, Cuny E, Aouizerate B, Pollak, P, Chabardes S, Polosan M, Borg M, Fontaine D, Giordana B, Raoul S, Rouaud T, Sauvaget A, Jalenques I, Karachi C, Mallet L. Anterior pallidal deep brain stimulation for Tourette’s syndrome: a double-blind randomised parallel controlled trial. Lancet Neurology, Published online June 20, 2017 http://dx.doi.org/10.1016/S1474-4422(17)30160-6

Yrondi, D. Bennabi, E. Haffen, M. Garnier, F. Bellivier, T. Bourgerol, V. Camus, T. D’Amato, O. Doumy, F. Haesebaert, J. Holtzmann, C. Lançon, P. Vignaud, F. Moliere, I. Nieto, R. M. M. Richieri, P. Domenech, C. Rabu, L. Mallet, L. Yon, L. Schmitt, F. Stephan, G. Vaiva, M. Walter, P.-M. M. Llorca, P. Courtet, M. Leboyer, W. El-Hage, and B. Aouizerate, Significant Need for a French Network of Expert Centers Enabling a Better Characterization and Management of Treatment-Resistant Depression (Fondation FondaMental). Front Psychiatry. 2017;8(NOV):244.

Doukhan, R., Mallet, L., & Pelissolo, A. A case of bleach addiction associated with severe obsessive-compulsive disorder. Revista Brasileira de Psiquiatria, 2017,  39(2), 187-188.

Flores Alves Dos Santos J, Tézenas du Montcel S, Gargiulo M, Behar C, Montel S, Hergueta T, Navarro S, Belaid H, Cloitre P, Karachi V, Mallet L, Welter M-L, Tackling the psychosocial maladjustment in Parkinson’s disease patients following subthalamic deep-brain stimulation: a randomised clinical trial. PLoS ONE, 12(4): e0174512. https://doi.org/10.1371/journal. pone.0174512

Benzina, N., Mallet, L., Burguière, E., N’Diaye, K., & Pelissolo, A.. Cognitive Dysfunction in Obsessive-Compulsive Disorder. Current Psychiatry Reports 2016, 1–11. http://doi.org/10.1007/s11920-016-0720-3

Gasnier, M., Pelissolo, A., Bondolfi, G., Pelissolo, S., Tomba, M., Mallet, L., & N’diaye, K. Les interventions basées sur la pleine conscience dans le trouble obsessionnel compulsif: mécanismes d’action et présentation d’une étude pilote. L’Encéphale 2016. http://dx.doi.org/10.1016/j.encep.2016.10.004

Morgiève M., N’Diaye K., Fernandez-Vidal S., Clair A.-H., & Mallet L. Le trouble obsessionnel compulsif vu par ceux qui y sont confrontés: enquête auprès de patients, de proches et de cliniciens. L’Encéphale 2016. http://dx.doi.org/10.1016/j.encep.2016.07.004

Morgiève M, N’Diaye K, Clair A.H., Pelissolo A, and Mallet L, “[Can the efficacy of behavioral and cognitive therapy for obsessive compulsive disorder be augmented by innovative computerized adjuvant?],” L’Encéphale 2016; 42: 402–409

  1. Deeb, P. J. Rossi, M. Porta, V. Visser-Vandewalle, D. Servello, P. Silburn, T. Coyne, J. F. Leckman, T. Foltynie, M. Hariz, E. M. Joyce, L. Zrinzo, Z. Kefalopoulou, M.-L. Welter, C. Karachi, L. Mallet, J.-L. Houeto, J. Shahed-Jimenez, F.-G. Meng, B. T. Klassen, A. Y. Mogilner, M. H. Pourfar, J. Kuhn, L. Ackermans, T. Kaido, Y. Temel, R. E. Gross, H. C. Walker, A. M. Lozano, S. M. Khandhar, B. L. Walter, E. Walter, Z. Mari, B. K. Changizi, E. Moro, J. C. Baldermann, D. Huys, S. E. Zauber, L. E. Schrock, J.-G. Zhang, W. Hu, K. D. Foote, K. Rizer, J. W. Mink, D. W. Woods, A. Gunduz, and M. S. Okun, “The International Deep Brain Stimulation Registry and Database for Gilles de la Tourette Syndrome: How Does It Work?,” Front. Neurosci. 2016, vol. 10, p. 1068, Apr. 2016.

Pelissolo A, Moukheiber A, Mallet L: Obsessive-compulsive disorders and anxiety disorders: A comparison of personality and emotionality patterns  Psychiatry Research 2015; 229:695–701

Alonso P, Cuadras D, Gabriëls L, Denys D, Goodman W, Greenberg BD, Jiménez-Ponce F, Kuhn J, Lenartz D, Mallet L, Nuttin B, Real E, Segalàs C, Schuurman R, Tézenas du Montcel S, Menchon JM: Deep Brain Stimulation for Obsessive-Compulsive Disorder: A Meta-Analysis of Treatment Outcome and Predictors of Response. PLoS ONE 2015; 10:e0133591

Burguière E, Monteiro P, Mallet L, Feng G, Graybiel AM: Striatal circuits, habits, and implications for obsessive-compulsive disorder. Current Opinion in Neurobiology 2015; 30:59–65

Bally J, Lüscher C, Berney A, Mallet L, Pollak P, Santos J: [Deep brain stimulation: new targets and new indications]. Rev Med Suisse 2015; 11:977–80– 982

Welter M-L, Schupbach M, Czernecki V, Karachi C, Fernandez-Vidal S, Golmard J-L, Serra G, Navarro S, Welaratne A, Hartmann A, Mesnage V, Pineau F, Cornu P, Pidoux B, Worbe Y, Zikos P, Grabli D, Galanaud D, Bonnet A-M, Belaid H, Dormont D, Vidailhet M, Mallet L, Houeto J-L, Bardinet E, Yelnik J, Agid Y. Optimal target localisation for subthalamic stimulation in Parkinson’s disease patients. Neurology, March 19, 2014
DOI 10.1212/WNL.0000000000000315.

Dervaux A, Falissard B, Grohens M, Limosin F, Mercuel A, Triantafyllou M, Vidon G, Mallet L, Plaze M, Laqueille X, Bocher R. Psychiatry in 2030 ? Presse Médicale,  2014 Jan 15. pii: S0755-4982(13)00871-3.

Morgiève M*, N’Diaye*, Haynes WIA, Granger B, Clair A-H, Pelissolo A, Mallet L. Dynamics of psychotherapy-related cerebral haemodynamic changes in Obsessive Compulsive Disorder using a personalised exposure task in fMRI. Psychol Med, 2013 Sep 4:1-13.

Flores Alves dos Santos J, Mallet L. Synthèse : Le Trouble Obsessionnel Compulsif. Médecine/Sciences, 2013 Dec;29(12):1111-6

Flores Alves dos Santos J, Mallet L. [OCD: when limbic systems start looping…]. Rev Prat 2013; 63: 643-646.

Burbaud P, Clair AH, Langbour N, Fernandez-Vidal S, Goillandeau M, Michelet T, Bardinet E, Chéreau I, Durif F, Polosan M, Chabardès S, Fontaine D, Magnié-Mauro MN, Houeto JL, Bataille B, Millet B, Vérin M, Baup N, Krebs MO, Cornu P, Pelissolo A, Arbus C, Simonetta-Moreau M, Yelnik J, Welter ML, Mallet L. Neuronal activity correlated with checking behaviour in the subthalamic nucleus of OCD patients. Brain, 2013 Jan;136(Pt 1):304-17

Clair AH, N’Diaye K, Baroukh T, Pochon JB, Morgieve M, Hantouche E, Falissard B, Pelissolo A, Mallet L. Excessive checking for non-anxiogenic stimuli in obsessive-compulsive disorder. Eur Psychiatry 2012. 10.1016/j.eurpsy.2012.11.003

Buot A, Welter ML, Karachi C, Pochon JB, Bardinet E, Yelnik J, Mallet L. Processing of emotional information in the human subthalamic nucleus. J Neurol Neurosurg Psychiatry 2012, 84, 1331+

Evans D, Mallet L, Flahault A, Cothereau C, Velazquez S, Capron L, Lejoyeux M. The importance of both workplace and private life factors in psychological distress: a large cross-sectional survey of French railway company employees. Social psychiatry and psychiatric epidemiology 2012. 10.1007/s00127-012-0605-7

Brun Y, Karachi C, Fernandez-Vidal S, Jodoin N, Grabli D, Bardinet E, Mallet L, Agid Y, Yelnik J, Welter ML. Does unilateral basal ganglia activity functionally influence the contralateral side? What we can learn from STN stimulation in patients with Parkinson’s disease. J Neurophysiol 2012; 108: 1575-1583.

Haynes WI, Millet B, Mallet L. [Obsessive-compulsive disorder, a new model of basal ganglia dysfunction? Elements from deep brain stimulation studies]. Rev Neurol (Paris) 2012; 168: 649-654.

Palminteri S, Clair AH, Mallet L, Pessiglione M. Similar improvement of reward and punishment learning by serotonin reuptake inhibitors in obsessive-compulsive disorder. Biol Psychiatry 2012; 72: 244-250.

Baunez C, Yelnik J, Mallet L. Six questions on the subthalamic nucleus: lessons from animal models and from stimulated patients. Neuroscience 2011; 198: 193-204.                IF: 3,4       C

Vorspan F, Mallet L, Corvol JC, Pelissolo A, Lepine JP. Treating addictions with deep brain stimulation is premature but well-controlled clinical trials should be performed. Addiction 2011; 106: 1535-1536; author reply 1537-1538.

Bourredjem A, Pelissolo A, Rotge JY, Jaafari N, Machefaux S, Quentin S, Bui E, Bruno N, Pochon JB, Polosan M, Baup N, Papetti F, Chereau I, Arbus C, Mallet L, du Montcel ST. A video Clinical Global Impression (CGI) in obsessive compulsive disorder. Psychiatry Res 2011; 186: 117-122.

Welter ML, Burbaud P, Fernandez-Vidal S, Bardinet E, Coste J, Piallat B, Borg M, Besnard S, Sauleau P, Devaux B, Pidoux B, Chaynes P, Tezenas du Montcel S, Bastian A, Langbour N, Teillant A, Haynes W, Yelnik J, Karachi C, Mallet L. Basal ganglia dysfunction in OCD: subthalamic neuronal activity correlates with symptoms severity and predicts high-frequency stimulation efficacy. Transl Psychiatry 2011; 1: e5.

Le Jeune F, Verin M, N’Diaye K, Drapier D, Leray E, Du Montcel ST, Baup N, Pelissolo A, Polosan M, Mallet L, Yelnik J, Devaux B, Fontaine D, Chereau I, Bourguignon A, Peron J, Sauleau P, Raoul S, Garin E, Krebs MO, Jaafari N, Millet B. Decrease of prefrontal metabolism after subthalamic stimulation in obsessive-compulsive disorder: a positron emission tomography study. Biol Psychiatry 2010; 68: 1016-1022.

Worbe Y, Mallet L, Golmard JL, Behar C, Durif F, Jalenques I, Damier P, Derkinderen P, Pollak P, Anheim M, Broussolle E, Xie J, Mesnage V, Mondon K, Viallet F, Jedynak P, Ben Djebara M, Schupbach M, Pelissolo A, Vidailhet M, Agid Y, Houeto JL, Hartmann A. Repetitive behaviours in patients with Gilles de la Tourette syndrome: tics, compulsions, or both? PLoS One 2010; 5: e12959.

Haynes WIA, Mallet L. High-frequency stimulation of deep brain structures in obsessive-compulsive disorder: the search for a valid circuit. European Journal of Neuroscience 2010; 32: 1118-1127.

Aouizerate B, Cuny E, Bardinet E, Yelnik J, Martin-Guehl C, Rotge JY, Rougier A, Bioulac B, Tignol J, Mallet L, Burbaud P, Guehl D. Distinct striatal targets in treating obsessive-compulsive disorder and major depression. J Neurosurg 2009; 111: 775-779.

Ribeiro MJ, Thobois S, Lohmann E, du Montcel ST, Lesage S, Pelissolo A, Dubois B, Mallet L, Pollak P, Agid Y, Broussolle E, Brice A, Remy P. A Multitracer Dopaminergic PET Study of Young-Onset Parkinsonian Patients With and Without Parkin Gene Mutations. J Nucl Med 2009.

Lohmann E, Thobois S, Lesage S, Broussolle E, du Montcel ST, Ribeiro MJ, Remy P, Pelissolo A, Dubois B, Mallet L, Pollak P, Agid Y, Brice A. A multidisciplinary study of patients with early-onset PD with and without parkin mutations. Neurology 2009; 72: 110-116.

Welter ML, Pelissolo A, Mallet L. Subthalamic Nucleus Stimulation in Severe Obsessive-Compulsive Disorder – Reply. N Engl J Med 2008; 360: 932-932.

Mallet L, Polosan M, Jaafari N, Baup N, Welter ML, Fontaine D, du Montcel ST, Yelnik J, Chereau I, Arbus C, Raoul S, Aouizerate B, Damier P, Chabardes S, Czernecki V, Ardouin C, Krebs MO, Bardinet E, Chaynes P, Burbaud P, Cornu P, Derost P, Bougerol T, Bataille B, Mattei V, Dormont D, Devaux B, Verin M, Houeto JL, Pollak P, Benabid AL, Agid Y, Krack P, Millet B, Pelissolo A. Subthalamic nucleus stimulation in severe obsessive-compulsive disorder. N Engl J Med 2008; 359: 2121-2134.

Rotge JY, Clair AH, Jaafari N, Hantouche EG, Pelissolo A, Goillandeau M, Pochon JB, Guehl D, Bioulac B, Burbaud P, Tignol J, Mallet L, Aouizerate B. A challenging task for assessment of checking behaviors in obsessive-compulsive disorder. Acta Psychiatr Scand 2008; 117: 465-473.

Welter ML*, Mallet L*, Houeto JL, Karachi C, Czernecki V, Cornu P, Navarro S, Pidoux B, Dormont D, Bardinet E, Yelnik J, Damier P, Agid Y. Internal pallidal and thalamic stimulation in patients with Tourette syndrome. Arch Neurol 2008; 65: 952-957.

Montefiore D, Mallet L, Levy R, Allilaire JF, Pelissolo A. [Pseudo-dementia conversion and post-traumatic stress disorder]. Encephale 2007; 33: 352-355.

Mallet L, Schupbach M, N’Diaye K, Remy P, Bardinet E, Czernecki V, Welter ML, Pelissolo A, Ruberg M, Agid Y, Yelnik J. Stimulation of subterritories of the subthalamic nucleus reveals its role in the integration of the emotional and motor aspects of behavior. Proc Natl Acad Sci U S A 2007; 104: 10661-10666.

Schupbach WM, Maltete D, Houeto JL, du Montcel ST, Mallet L, Welter ML, Gargiulo M, Behar C, Bonnet AM, Czernecki V, Pidoux B, Navarro S, Dormont D, Cornu P, Agid Y. Neurosurgery at an earlier stage of Parkinson disease: a randomized, controlled trial. Neurology 2007; 68: 267-271.

Schupbach MW, Welter ML, Bonnet AM, Elbaz A, Grossardt BR, Mesnage V, Houeto JL, Maltete D, Mallet L, Rocca WA, Mallet A, Agid Y. Mortality in patients with Parkinson’s disease treated by stimulation of the subthalamic nucleus. Mov Disord 2007; 22: 257-261.

Diallo R, Welter ML, Mallet L. Therapeutic management of tics in Tourette’s syndrome. Rev Neurol (Paris) 2007; 163: 375-386.

Ardouin C, Voon V, Worbe Y, Abouazar N, Czernecki V, Hosseini H, Pelissolo A, Moro E, Lhommee E, Lang AE, Agid Y, Benabid AL, Pollak P, Mallet L, Krack P. Pathological gambling in Parkinson’s disease improves on chronic subthalamic nucleus stimulation. Mov Disord 2006; 21: 1941-1946.              

Schupbach M, Gargiulo M, Welter ML, Mallet L, Behar C, Houeto JL, Maltete D, Mesnage V, Agid Y. Neurosurgery in Parkinson disease: a distressed mind in a repaired body? Neurology 2006; 66: 1811-1816.

Houeto JL, Mallet L, Mesnage V, Tezenas du Montcel S, Behar C, Gargiulo M, Torny F, Pelissolo A, Welter ML, Agid Y. Subthalamic stimulation in Parkinson disease: behavior and social adaptation. Arch Neurol 2006; 63: 1090-1095.

Mallet L. [Profound cerebral stimulation: its usefulness for the therapeutic modulation of behavior and emotions]. Encephale 2006; 32: S44-47.

Agid Y, Schupbach M, Gargiulo M, Mallet L, Houeto JL, Behar C, Maltete D, Mesnage V, Welter ML. Neurosurgery in Parkinson’s disease: the doctor is happy, the patient less so? J Neural Transm Suppl 2006: 409-414.

Houeto JL, Karachi C, Mallet L, Pillon B, Yelnik J, Mesnage V, Welter ML, Navarro S, Pelissolo A, Damier P, Pidoux B, Dormont D, Cornu P, Agid Y. Tourette’s syndrome and deep brain stimulation. J Neurol Neurosurg Psychiatry 2005; 76: 992-995.

Mallet L. [Bipolar symptoms, frontal lobe symptoms]. Encephale 2005; 31: S12-15.

Schupbach WM, Chastan N, Welter ML, Houeto JL, Mesnage V, Bonnet AM, Czernecki V, Maltete D, Hartmann A, Mallet L, Pidoux B, Dormont D, Navarro S, Cornu P, Mallet A, Agid Y. Stimulation of the subthalamic nucleus in Parkinson’s disease: a 5 year follow up. J Neurol Neurosurg Psychiatry 2005; 76: 1640-1644.    

Pelissolo A, Mallet L, Baleyte JM, Michel G, Cloninger CR, Allilaire JF, Jouvent R. The Temperament and Character Inventory-Revised (TCI-R): psychometric characteristics of the French version. Acta Psychiatr Scand 2005; 112: 126-133.

Houeto JL, Mesnage V, Welter ML, Mallet L, Agid Y, Bejjani BP. Subthalamic DBS replaces levodopa in Parkinson’s disease: two-year follow-up. Neurology 2003; 60: 154-155; author reply 154-155.

Mallet L, Mesnage V, Houeto JL, Pelissolo A, Yelnik J, Behar C, Gargiulo M, Welter ML, Bonnet AM, Pillon B, Cornu P, Dormont D, Pidoux B, Allilaire JF, Agid Y. Compulsions, Parkinson’s disease, and stimulation. Lancet 2002; 360: 1302-1304.

Houeto JL, Mesnage V, Mallet L, Pillon B, Gargiulo M, du Moncel ST, Bonnet AM, Pidoux B, Dormont D, Cornu P, Agid Y. Behavioural disorders, Parkinson’s disease and subthalamic stimulation. J Neurol Neurosurg Psychiatry 2002; 72: 701-707.

Paillere-Martinot M, Caclin A, Artiges E, Poline JB, Joliot M, Mallet L, Recasens C, Attar-Levy D, Martinot JL. Cerebral gray and white matter reductions and clinical correlates in patients with early onset schizophrenia. Schizophr Res 2001; 50: 19-26.

Xiberas X, Martinot JL, Mallet L, Artiges E, Loc HC, Maziere B, Paillere-Martinot ML. Extrastriatal and striatal D(2) dopamine receptor blockade with haloperidol or new antipsychotic drugs in patients with schizophrenia. Br J Psychiatry 2001; 179: 503-508.

Xiberas X, Martinot JL, Mallet L, Artiges E, Canal M, Loc’h C, Maziere B, Paillere-Martinot ML. In vivo extrastriatal and striatal D2 dopamine receptor blockade by amisulpride in schizophrenia. J Clin Psychopharmacol 2001; 21: 207-214.

Falissard B, Corruble E, Mallet L, Hardy P. Focused Principal Component Analysis : A promising approach for confirming findings of exploratory analyses ? International Journal of Methods in Psychiatric Research 2001; 10: 191-195.

Doyen C, Mallet L, Falissard B, Bouvard MP, Dugas M, Mouren-Simeoni MC. Abnormal psychosocial situations among inpatients from a child and adolescent psychiatric department in a teaching hospital in France. Eur Child Adolesc Psychiatry 1999; 8: 207-213.

Mallet L, Mazoyer B, Martinot JL. Functional connectivity in depressive, obsessive-compulsive, and schizophrenic disorders: an explorative correlational analysis of regional cerebral metabolism. Psychiatry Res 1998; 82: 83-93.