phone: +33 1 57 27 44 25
phone: +33 1 57 27 44 25
I have been trained as a neurophysiologist specialized in behavior, neuronal recording and optogenetic approaches with rodent models. Along my scientific career I specialized in developing innovative paradigms to study behavioural adaptation and regulation. I studied mouse models of disorders of motor and cognitive functions. Importantly, I became an expert in pathophysiology of repetitive behaviors, notably with some recent work on compulsive behaviors of a mouse model of OCD-spectrum disorder (Burguière et al., Science 2013).
Recently, I developed with my research group some innovative approaches that we can modulate specific brain activities in a closed-loop design, either at rest or within a task. We developed innovative operant chambers where mice are performing complex cognitive tasks while their social, circadian and cognitive behaviours are monitored automatically and continuously using multiple sensors.
2018 HDR in Neurophysiology, Univ. Paris 6, France.
2007 PhD in Neuroscience/Cognitive Science. Univ. Paris 6, France.
2002 Master’s Degree in Cognitive Science. Univ. Paris 6, France.
2001 Degree in Neurophysiology and Cellular Biology Univ. Paris 6, France.
Training and Professional Experience
2019-present Team Leader of the “Neurophysiology of Repetitive Behaviors” lab, ICM, France.
2014-present Tenured research scientist at the Paris Brain Institute (ICM), Paris, France.
2007-2013 Post-doctorate associate. Graybiel laboratory, MIT, Cambridge, USA.
2002-2006 PhD student. Collège de France, Paris, France.
2004 Research Assistant IRCCS, Santa Lucia, Roma, Italy.
2000 Research Assistant University of Portsmouth, Portsmouth, England.
PUBLICATIONS AND PROCEEDINGS
Schreiweis C, Irinopoulou T, Vieth B, …, Burguière E, Enard W, Groszer M. (2019). Mice carrying a humanized Foxp2 knock-in allele show region-specific shifts of striatal Foxp2 expression levels. Cortex, Sep;118:212-222.
Benzina N, N’Diaye K, Pelissolo A, Mallet L, Burguière E (2019). A cross-species assessment of cognitive flexibility in compulsive disorders. BioRxiv, https://doi.org/10.1101/542100
Mondragon L. & Burguiere E. (2017). Bio-inspired benchmark generator for extracellular multi-unit recordings. Sci Rep 7, 43253.
Schreiweis, C.*, Bornschein, U.*, Burguiere, E., Kerimoglu, C., Schreiter, S., Dannemann, M., Goyal, S., Rea, E., French, C. A., Puliyadi, R., Groszer, M., Fisher, S. E., Mundry, R., Winter, C. et al. (2014). Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance. PNAS, 111(39), 14253-14258.
Burguiere E., Monteiro P., Feng G. P., & Graybiel A. M. (2013). Optogenetic Stimulation of Lateral Orbitofronto-Striatal Pathway Suppresses Compulsive Behaviors. Science, 340(6137), 1243-1246.
Burguière E., Arabo A., Jarlier F., De Zeeuw C.I., Rondi-Reig L. (2010). Role of the cerebellar cortex in conditioned goal-directed behavior. J Neurosci. Oct;30(40):13265-13271.
Burguière E., Arleo A., De Zeeuw C.I., Berthoz A., Rondi-Reig L. (2005). Spatial navigation impairment in mice lacking LTD: a motor adaptation deficit? Nat Neurosci. Oct;8(10):1292-4.
Schreiweis C, Volle E, Durr A, Auffret A, Delarasse C, George N , Dumont M, Hassan BA, Renier N, Rosso C, Thiebaut de Schotten M, Burguière E, Zujovic V. (2019) A neuroscientific approach to increase gender equality. Nat Hum Behav. 2019 Dec;3(12):1238-1239.
Benzina, N., Mallet, L., Burguiere, E., N’Diaye, K., & Pelissolo, A. (2016). Cognitive Dysfunction in Obsessive-Compulsive Disorder. Current Psychiatry Reports, 18(9).
Burguière, E., Monteiro, P., Mallet, L, Feng, G, Graybiel, A.M. (2015). Striatal circuits, habits, and implications for obsessive-compulsive disorder. Curr Opin Neurobiol. Sep 18;30C:59-65.
Rondi-Reig L, Burguière E. (2005). Is the cerebellum ready for navigation? Prog Brain Res.;148:199-212.
Zugaro MB, Arleo A, Déjean C, Burguière E, Khamassi M, Wiener SI. (2004) Rat anterodorsal thalamic head direction neurons depend upon dynamic visual signals to select anchoring landmark cues. Eur J Neurosci. Jul;20(2):530-6.
For a complete list of publications: https://scholar.google.com/citations?user=WWwjxIgAAAAJ&hl=fr&oi=ao
B Aouizerate, E Burguière, M Le Moal – (2017) 4.3 Modèles animaux en psychiatrie: principes généraux,: In Rouillon F. et Guelfi J-D. (eds) Manuel de Psychiatrie 3ème édition, Elsevier Masson.
Main conference invitations (last 5 years)
2020 International meeting of the Integrated Brain & Behavior research center (IBBRC), Haifa, Israel
2019 Swiss Fondamental Swiss Foundation meeting, Genova, Switzerland
2018 European Neuroscience meeting (FENS), Symposium chaired by R. Costa, Berlin, Germany
Conference “Optimizing animal models for neuropsychiatric disorders”, Cologne, Germany
Passwell annual conference “Bridging basic and translational science”, Weizmann Inst., Israel
2017 Annual “IoN-ICM students workshop”, University College of London, United Kingdom
2016 Conference European Winter Brain Conference meeting, Switzerland
Conference during the French American Innovation Days, Boston, USA
Seminar at the Herseninstituut, invited by Ingo Willhun, Amsterdam, Netherlands
2015 Inaugural lecture at the annual meeting of AP-HP, Paris, France
Conference Annual Cerebrovascular Disease Society meeting, Paris; France.
2014 Conference Psychiatric Disease and Animal Models symposium, Paris 8 University, France.
2013 Conference Society of Biological Psychiatry, San Francisco, USA
Conference French Society of Psychiatry, Nice, France
Fondation de France – Program « New avenues in Psychiatry » (2020-2023 ; Coordinator)
Closed-loop neurostimulation to prevent compulsive behaviors
ANR International Program (2019-2022; Coordinator)
Project DOPALOOPS: “Modulating the shift from goal-directed to habitual behaviors by manipulation of dopaminergic striatonigral loops”
ANR Young Investigator Program (2017-2021; Coordinator)
Project SINREP: “Role of the Striatal Inhibitory Networks in Repetitive Behaviors”
Labex consortium BIOPSY + IHU Translational Neuroscience (2016-2018; Co-coordinator)
Project DECIMOTIV: “Motivation and Decision”
2013 Prize for the best scientific article of the year (French Society of Psychiatry).
2007 Prize for the best neuroscience PhD thesis of the year (French Society of Neuroscience).
2005 Prize attributed by Lilly Institute for the PhD work accomplished.
2013 FRM Foundation for 2 years of funding as a research scientist.
2010 Simons Foundation for a 2 years postdoctoral fellowship.
2007 EMBO for a 2 years postdoctoral fellowship.
2002 University Paris 6 for pursuing a 3 years PhD project.
Teaching and conference organization
Neuroscience master program BIP, Sorbonne University, Paris, France.
Neuroscience master program, Ecole Normale Supérieure, Cachan, France.
Biological Psychiatry Summer School, Institut Pasteur, Paris, France
Organizer of an international conference on open neuroscience (200 attendants), ICM, Paris.
Organizer of an international conference on optogenetic (200 attendants), ICM, Paris.
Benchmark generator for simulating electrophysiological data (2017) (Open-access, SL Mondragon and E Burguière, Scientific Reports publication)
2019: Seminar at Pasteur Institute, Paris, France
2017: Seminars at Institut Fer à Moulin and Poitiers university, Paris, France.
2016: Seminar at the Herseninstituut, invited by Ingo Willhun, Amsterdam, Netherlands; Seminar at Cognitive Science Institute, invited by Leon Tremblay, Lyon, France.
2015: Seminar at the Laboratory of cognitive science, invited by Bruno Poucet, Marseille, France.
2013: Seminar at Mayo Clinic, invited by Kendall Lee, Rochester, USA.