Eric Burguière

Eric Burguière

Team leader

e-mail: eric.burguire(at)icm-institute.org

phone: +33 1 57 27 44 25

 

I have been trained as a neurophysiologist specialized in behavior, neuronal recording and optogenetic approaches with rodent models. Along my scientific career I specialized in developing innovative paradigms to study behavioural adaptation and regulation. I studied mouse models of disorders of motor and cognitive functions. Importantly, I became an expert in pathophysiology of repetitive behaviors, notably with some recent work on compulsive behaviors of a mouse model of OCD-spectrum disorder (Burguière et al., Science 2013).

Recently, I developed with my research group some innovative approaches that we can modulate specific brain activities in a closed-loop design, either at rest or within a task. We developed innovative operant chambers where mice are performing complex cognitive tasks while their social, circadian and cognitive behaviours are monitored automatically and continuously using multiple sensors.

Educational Background

2018 HDR in Neurophysiology, Univ. Paris 6, France.

2007 PhD in Neuroscience/Cognitive Science. Univ. Paris 6, France.

2002 Master’s Degree in Cognitive Science. Univ. Paris 6, France.

2001 Degree in Neurophysiology and Cellular Biology Univ. Paris 6, France.

 

Training and Professional Experience

2019-present     Team Leader of the “Neurophysiology of Repetitive Behaviors” lab, ICM, France.

2014-present     Tenured research scientist at the Paris Brain Institute (ICM), Paris, France.

2007-2013            Post-doctorate associate. Graybiel laboratory, MIT, Cambridge, USA.

2002-2006            PhD student. Collège de France, Paris, France.

2004                       Research Assistant IRCCS, Santa Lucia, Roma, Italy.

2000                      Research Assistant University of Portsmouth, Portsmouth, England.

PUBLICATIONS AND PROCEEDINGS

Journal articles

Main publications

Schreiweis C, Irinopoulou T, Vieth B, …, Burguière E, Enard W, Groszer M. (2019). Mice carrying a humanized Foxp2 knock-in allele show region-specific shifts of striatal Foxp2 expression levels. Cortex, Sep;118:212-222.

Benzina N, N’Diaye K, Pelissolo A, Mallet L, Burguière E (2019). A cross-species assessment of cognitive flexibility in compulsive disorders. BioRxiv, https://doi.org/10.1101/542100

Mondragon L. & Burguiere E. (2017). Bio-inspired benchmark generator for extracellular multi-unit recordings. Sci Rep 7, 43253.

Schreiweis, C.*, Bornschein, U.*, Burguiere, E., Kerimoglu, C., Schreiter, S., Dannemann, M., Goyal, S., Rea, E., French, C. A., Puliyadi, R., Groszer, M., Fisher, S. E., Mundry, R., Winter, C. et al. (2014). Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance. PNAS, 111(39), 14253-14258.

Burguiere E., Monteiro P., Feng G. P., & Graybiel A. M. (2013). Optogenetic Stimulation of Lateral Orbitofronto-Striatal Pathway Suppresses Compulsive Behaviors. Science, 340(6137), 1243-1246.

Burguière E., Arabo A., Jarlier F., De Zeeuw C.I., Rondi-Reig L. (2010). Role of the cerebellar cortex in conditioned goal-directed behavior. J Neurosci. Oct;30(40):13265-13271.

Burguière E., Arleo A., De Zeeuw C.I., Berthoz A., Rondi-Reig L. (2005). Spatial navigation impairment in mice lacking LTD: a motor adaptation deficit? Nat Neurosci. Oct;8(10):1292-4.

 

Other publications

 

Schreiweis C, Volle E, Durr A, Auffret A, Delarasse C, George N , Dumont M, Hassan BA, Renier N, Rosso C, Thiebaut de Schotten M, Burguière E, Zujovic V. (2019)  A neuroscientific approach to increase gender equality. Nat Hum Behav. 2019 Dec;3(12):1238-1239.

Benzina, N., Mallet, L., Burguiere, E., N’Diaye, K., & Pelissolo, A. (2016). Cognitive Dysfunction in Obsessive-Compulsive Disorder. Current Psychiatry Reports, 18(9).

Burguière, E., Monteiro, P., Mallet, L, Feng, G, Graybiel, A.M. (2015). Striatal circuits, habits, and implications for obsessive-compulsive disorder. Curr Opin Neurobiol. Sep 18;30C:59-65.

Rondi-Reig L, Burguière E. (2005). Is the cerebellum ready for navigation? Prog Brain Res.;148:199-212.

Zugaro MB, Arleo A, Déjean C, Burguière E, Khamassi M, Wiener SI. (2004) Rat anterodorsal thalamic head direction neurons depend upon dynamic visual signals to select anchoring landmark cues. Eur J Neurosci. Jul;20(2):530-6.

 

For a complete list of publications: https://scholar.google.com/citations?user=WWwjxIgAAAAJ&hl=fr&oi=ao

 

Book chapters

  1. Burguière, L. Mallet (In Press), Basic mechanisms of and treatment planning for OCD; in Geddes JR, Andreasen NC and Goodwin GM (Eds). The New Oxford Textbook of Psychiatry 3edn. Oxford University Press, Oxford, UK.

B Aouizerate, E Burguière, M Le Moal – (2017) 4.3 Modèles animaux en psychiatrie: principes généraux,: In Rouillon F. et Guelfi J-D. (eds) Manuel de Psychiatrie 3ème édition, Elsevier Masson.

Main conference invitations (last 5 years)

2020       International meeting of the Integrated Brain & Behavior research center (IBBRC), Haifa, Israel

2019       Swiss Fondamental Swiss Foundation meeting, Genova, Switzerland

2018      European Neuroscience meeting (FENS), Symposium chaired by R. Costa, Berlin, Germany

                Conference “Optimizing animal models for neuropsychiatric disorders”, Cologne, Germany

                Passwell annual conference “Bridging basic and translational science”, Weizmann Inst., Israel

2017       Annual “IoN-ICM students workshop”, University College of London, United Kingdom

2016      Conference European Winter Brain Conference meeting, Switzerland

                Conference during the French American Innovation Days, Boston, USA

                Seminar at the   Herseninstituut, invited by Ingo Willhun, Amsterdam, Netherlands

2015      Inaugural lecture at the annual meeting of AP-HP, Paris, France

                Conference Annual Cerebrovascular Disease Society meeting, Paris; France.

2014      Conference Psychiatric Disease and Animal Models symposium, Paris 8 University, France.

2013      Conference Society of Biological Psychiatry, San Francisco, USA

                Conference French Society of Psychiatry, Nice, France

 

Major Grants

Fondation de France – Program « New avenues in Psychiatry » (2020-2023 ; Coordinator)

Closed-loop neurostimulation to prevent compulsive behaviors

 

ANR International Program (2019-2022; Coordinator)

Project DOPALOOPS: “Modulating the shift from goal-directed to habitual behaviors by manipulation of dopaminergic striatonigral loops”

 

ANR Young Investigator Program (2017-2021; Coordinator)

Project SINREP: “Role of the Striatal Inhibitory Networks in Repetitive Behaviors”

 

Labex consortium BIOPSY + IHU Translational Neuroscience (2016-2018; Co-coordinator)

Project DECIMOTIV: “Motivation and Decision”

Prizes

2013       Prize for the best scientific article of the year (French Society of Psychiatry).

2007       Prize for the best neuroscience PhD thesis of the year (French Society of Neuroscience).

2005       Prize attributed by Lilly Institute for the PhD work accomplished.

Awards

2013       FRM Foundation for 2 years of funding as a research scientist.

2010       Simons Foundation for a 2 years postdoctoral fellowship.

2007       EMBO for a 2 years postdoctoral fellowship.

2002       University Paris 6 for pursuing a 3 years PhD project.

Teaching and conference organization

 

Teaching activity

Since 2016         

Neuroscience master program BIP, Sorbonne University, Paris, France.

Neuroscience master program, Ecole Normale Supérieure, Cachan, France.

2015      

Biological Psychiatry Summer School, Institut Pasteur, Paris, France

Conference Organization

2019

Organizer of an international conference on open neuroscience (200 attendants), ICM, Paris.

2016

Organizer of an international conference on optogenetic (200 attendants), ICM, Paris.

Conference proceedings

2019   

  1. Lamothe, H., Poupon,C., Poupon, F., Mallet, L., Burguière, E.: Anatomical characterization of the cortico-striatal circuits in SAPAP3-KO mice by high definition fiber tractography. Meeting of the International Basal Ganglia Society (IBAGS). Biarritz, France
  2. Euvrard, N. Benzina, Y. Travert, P. Tissier, G. Penderia, E. Burguiere: The Behavioural and Ecological Automated operanT Box (BEATBox): a flexible and low-cost system for high-throughput behavioural data acquisition. Meeting of the International Basal Ganglia Society (IBAGS). Biarritz, France.

 

2018   

  1. Euvrard, P. Domenech, E. Burguière. A translational study to behaviorally, computationally and neurophysiologically  investigate the exploration – exploitation trade-off. ICM-ION Workshop, Paris, France.
  2. Lavielle, C. Schreiweis, E. Burguière. The role of striatal parvalbumin interneurons in perceptual decision-making. ICM-IoN Workshop, Paris, France
  3. Schreiweis, M. Gacoin, G. Penderia, J. Daunizeau*, E. Burguière*. Probing the motivational control of decision making in mice using an in-house automatized, high throughput behavioral task. Justen Passwell Syposium, Rehovot, Israel.
  4. Schreiweis, C., Gacoin, M., Penderia, G., Daunizeau, J.*, Burguière, E.*: Motivational control of decision making in mice using an automated, high throughput behavioral task. Annual Meeting of the Federation of European Neuroscience (FENS). Berlin, Germany.

 

2017   

  1. L. Mondragon, E. Burguière. Combining a real-time closed-loop approach with optogenetics: An integrative approach to investigate the pathophysiology of repetititve behaviors. OPTO-DBS congress, Genova, Switzerland.
  2. Schreiweis, C., Gacoin, M., Penderia, G., Daunizeau, J.*, Burguière, E.*: Probing the motivational control of decision making in mice using an automated, high throughput behavioral task. Annual Meeting of the Society for Neuroscience (SfN). Washington DC, USA.
  3. E Lousada, C Schreiweis, B Nait Oumesmar, E Burguière. Cortico-striatal myelination in the context of pathologically repetitive behaviours. RIKEN BSI Summer Program, Kyoto, Japan.
  4. Benzina, K. N’diaye, L. Mallet and E. Burguière. Neuromodulation of the hyperdirect pathway to study flexibility as an endophenotype of obsessive compulsive disorders. Conference “Science of Translation: Optimizing Animal Models for Neuropsychiatry”, Koln, Germany.

2016   

  1. Benzina, K. N’diaye, L. Mallet and E. Burguière. Neuromodulation of the hyperdirect pathway to study flexibility as an endophenotype of obsessive compulsive disorders. Synapsy congress, Genova, Switzerland.
  2. Schreiweis, U. Bornschein, E. Burguière, et al.: The human version of Foxp2, a gene implied in language and speech acquisition, accelerates proceduralization during learning. Dopamine 2016 Symposium, Vienna, Austria.
  3. Benzina, K. N’diaye, L. Mallet and E. Burguière. Neuromodulation of the hyperdirect pathway to study flexibility as an endophenotype of obsessive compulsive disorders. 2nd International congress on DBS, Dusseldorf, Germany.
  4. Lamothe H., Valabrègue R., Santin M., Petiet A., Mallet L., Burguière E. Movement disorders or compulsions? Anatomical and functional characterization of SAPAP3 mutant mouse model. Workshop ICM Imaging platform, Paris, France.
  5. L. Mondragon, E. Burguière. Open-source tools for electrophysiology and optogenetics. Congress “Opto-ICM”, Paris, France.

2015    

  1. Benzina, SL Mondragon, N Ouarti, L. Mallet and E. Burguière. Neurocognitive basis of compulsive behavior: a translational approach. Opto-DBS conference, Genova, Switzerland.
  2. SL Mondragon, N Ouarti, E. Burguière. A millisecond short-latency reprogrammable silicon chip solution for the pre-processing of electrophysiological data: Towards a real-time closed-loop approach. Society for Neuroscience meeting, Chicago, USA.
  3. SL Mondragon, N Ouarti, E. Burguière. Generation of neurophysiological data-driven benchmark for evaluation of real time closed-loop system. Society for French Neuroscience meeting, Lyon, France.
  4. Benzina, SL Mondragon, N Ouarti, L. Mallet and E. Burguière. Neurocognitive basis of compulsive behavior: a translational approach. Society for French Neuroscience meeting, Lyon, France.

2014   

  1. Benzina, SL Mondragon, N Ouarti, L. Mallet and E. Burguière. Translational approach to study flexibility as an endophenotype of obsessive compulsive disorders. Society for Neuroscience meeting, Washington, USA.

Software

Benchmark generator for simulating electrophysiological data (2017) (Open-access, SL Mondragon and E Burguière, Scientific Reports publication)

 

Seminars

2019: Seminar at Pasteur Institute, Paris, France

2017: Seminars at Institut Fer à Moulin and Poitiers university, Paris, France.

2016: Seminar at the Herseninstituut, invited by Ingo Willhun, Amsterdam, Netherlands; Seminar at Cognitive Science Institute, invited by Leon Tremblay, Lyon, France.

2015: Seminar at the Laboratory of cognitive science, invited by Bruno Poucet, Marseille, France.

2013: Seminar at Mayo Clinic, invited by Kendall Lee, Rochester, USA.